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The influence of central administration of dopaminergic and cholinergic agents on morphine-induced amnesia in morphine-sensitized mice

Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran and School of Cognitive Science, Institute for Studies in Theoretical Physics and Mathematics, Tehran, Iran, zarinmr{at}ams.ac.ir

Maryam Farahmandfar

Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran

Parvin Rostami

Department of Biology, Teacher Training University, Tehran, Iran

Ameneh Rezayof

Department of Biology, Faculty of Science, Tehran University, Tehran, Iran

In the present study, effects of intracerebroventricular (i.c.v.) injections of dopaminergic and cholinergic agents on morphine-induced amnesia in morphine-sensitized mice were investigated by using a one-trial passive avoidance task. Amnesia induced by pre-training morphine was significantly reversed in morphine-sensitized mice, which had previously received once daily injections of morphine (20 and 30mg/kg, s.c.) for 3 days. Three daily injections of SKF 38393 (1, 2 and 4 g/mouse, i.c.v.) or SCH 23390 (0.25, 0.5, 0.75 and 1 g/mouse, i.c.v.) before morphine, and during morphine-sensitization, decreased and increased the amnesia induced by pre-training morphine respectively. Three daily injections of quinpirole (0.3, 1 and 3 g/mouse, i.c.v.) or sulpiride (0.03, 0.1, 0.3 and 1 g/mouse, i.c.v.) before morphine, also decreased and increased the amnesia induced by pre-training morphine respectively. Morphine-sensitized mice received similar injections of cholinergic agents. Three daily injections of physostigmine (1, 3 and 5 g/mouse, i.c.v.) or atropine (1, 4 and 7 g/mouse, i.c.v.) before morphine, and during morphine-sensitization, decreased and increased the amnesia induced by pre-training morphine respectively. Three daily injections of nicotine (0.75, 1 and 2 g/mouse, i.c.v.) or mecamylamine (1, 3 and 6 g/mouse, i.c.v.) before morphine, also decreased and increased the amnesia induced by pre-training morphine respectively. The results suggest that morphine sensitization affects the impairment of memory formation and thus it is postulated that central dopaminergic and cholinergic systems may play an important role in this effect.

Key Words: morphine • dopamine receptor agonists and antagonists • muscarinic and nicotinic receptor agonists and antagonists • sensitization • passive avoidance learning (mice)

This version was published on January 1, 2006

Journal of Psychopharmacology, Vol. 20, No. 1, 59-66 (2006)
DOI: 10.1177/0269881105057003


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