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The influence of central administration of dopaminergic and cholinergic agents on morphine-induced amnesia in morphine-sensitized mice

Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran and School of Cognitive Science, Institute for Studies in Theoretical Physics and Mathematics, Tehran, Iran, zarinmr{at}ams.ac.ir

Maryam Farahmandfar

Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran

Parvin Rostami

Department of Biology, Teacher Training University, Tehran, Iran

Ameneh Rezayof

Department of Biology, Faculty of Science, Tehran University, Tehran, Iran

In the present study, effects of intracerebroventricular (i.c.v.) injections of dopaminergic and cholinergic agents on morphine-induced amnesia in morphine-sensitized mice were investigated by using a one-trial passive avoidance task. Amnesia induced by pre-training morphine was significantly reversed in morphine-sensitized mice, which had previously received once daily injections of morphine (20 and 30mg/kg, s.c.) for 3 days. Three daily injections of SKF 38393 (1, 2 and 4 g/mouse, i.c.v.) or SCH 23390 (0.25, 0.5, 0.75 and 1 g/mouse, i.c.v.) before morphine, and during morphine-sensitization, decreased and increased the amnesia induced by pre-training morphine respectively. Three daily injections of quinpirole (0.3, 1 and 3 g/mouse, i.c.v.) or sulpiride (0.03, 0.1, 0.3 and 1 g/mouse, i.c.v.) before morphine, also decreased and increased the amnesia induced by pre-training morphine respectively. Morphine-sensitized mice received similar injections of cholinergic agents. Three daily injections of physostigmine (1, 3 and 5 g/mouse, i.c.v.) or atropine (1, 4 and 7 g/mouse, i.c.v.) before morphine, and during morphine-sensitization, decreased and increased the amnesia induced by pre-training morphine respectively. Three daily injections of nicotine (0.75, 1 and 2 g/mouse, i.c.v.) or mecamylamine (1, 3 and 6 g/mouse, i.c.v.) before morphine, also decreased and increased the amnesia induced by pre-training morphine respectively. The results suggest that morphine sensitization affects the impairment of memory formation and thus it is postulated that central dopaminergic and cholinergic systems may play an important role in this effect.

Key Words: morphine • dopamine receptor agonists and antagonists • muscarinic and nicotinic receptor agonists and antagonists • sensitization • passive avoidance learning (mice)

References

• Bartoletti M, Gaiardi M, Gubellini C, Bacchi A, Babbini M (1987) Previous treatment with morphine and sensitization to the excitatory actions of opiates: dose-effect relationship . Neuropharmacology 26: 115-119 [Medline] [Order article via Infotrieve]
• Beninger R J, Miller R (1998) Dopamine D1-like receptors and reward-related incentive learning . Neurosci Biobehav Rev 22: 335-345 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Bruins Slot L A, Colpaert F C (1999a) Opiates states of memory: receptor mechanisms . J Neurosci 19: 10520-10529 [Abstract/Free Full Text]
• Bruins Slot L A, Colpaert F C (1999b) Recall rendered dependent on an opiate state . Behav Neurosci 113: 337-344 [CrossRef][Medline] [Order article via Infotrieve]
• Castellano C (1975) Effects of morphine and heroin on discrimination learning and consolidation in mice . Psychopharmacology 42: 235-242 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• De Fonseca F R D, Rubio P, Martin-Caldon J L, Caine S B, Koob G F, Navarro M (1995) The dopamine receptor agonist 7-OH-DPAT modulates the acquisition and expression of morphine-induced place preference . Eur J Pharmacol 274: 47-55 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Del Rosario C N, Pacchioni A M, Cancela L M (2002) Influence of acute or repeated restraint stress on morphine-induced locomotion: involvement of dopamine, opioid and glutamate receptors . Behav Brain Res 134: 229-238 [Medline] [Order article via Infotrieve]
• Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats . Proc Natl Acad Sci USA 85: 5274-5279 [Abstract/Free Full Text]
• Fiserova M, Consolo S, Krsiak M (1999) Chronic morphine induces long-lasting changes in acetylcholine release in rat nucleus accumbens core and shell: an in vivo microdialysis study . Psychopharmacology 142: 85-94 [CrossRef][Medline] [Order article via Infotrieve]
• Gold P E (2003) Acetylcholine modulation of neural systems involved in learning and memory . Neurobiol Learning Memory 80: 194-210 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Hiramatsu M, Sasaki M, Kameyama T (1995) Effects of dynorphin A-(1-13) on carbon monoxide-induced delayed amnesia in mice studied in step-down type passive avoidance task . Eur J Pharmacol 282: 185-191 [CrossRef][Medline] [Order article via Infotrieve]
• Imperato A, Obinu M C, Casu M A, Mascia M S, Carta G, Gessa G L (1996) Chronic morphine increases hippocampal acetylcholine release: possible relevance in drug dependence . Eur J Pharmacol 302: 21-26 [Medline] [Order article via Infotrieve]
• Izquierdo I (1979) Effects of naloxone and morphine on various forms of memory in the rat: possible role of endogenous opiate mechanisms in memory consolidation . Psychopharmacology 66: 199-203 [CrossRef][Medline] [Order article via Infotrieve]
• Izquierdo I, Schroder N, Netto C A, Medina J H (1999) Novelty causes time-dependent retrograde amnesia for one-trial avoidance in rats through NMDA receptor- and CaMKII-dependent mechanisms in the hippocampus . Eur J Neurosci 11: 3323-3328 [CrossRef][Medline] [Order article via Infotrieve]
• Jellestad F K, Bakke H K (1985) Passive avoidance after ibotenic acid and radio frequency lesions in the rat amygdala . Physiol Behav 34: 299-305 [Medline] [Order article via Infotrieve]
• Jeziorski M, White F J (1995) Dopamine receptor antagonists prevent expression, but not development, of morphine sensitization . Eur J Pharmacol 275: 235-244 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Kalivas P W, Stewart J (1991) Dopamine transmission in the initiation and expression drug- and stress-induced sensitization of motor activity . Brain Res Rev 16: 223-244 [CrossRef][Medline] [Order article via Infotrieve]
• Kuribara H (1995) Modification of morphine sensitization by opioid and dopamine receptor antagonists: evaluation by studying ambulation in mice . Eur J Pharmacol 14: 251-258
• McGaugh J L, Baratti C M (1985) Pharmacological evidence of a central effect of naltrexone, morphine, and beta-endorphin and a peripheral effect of met- and leu-enkephalin on retention of an inhibitory response in mice . Behav Neural Biol 44: 434-446 [CrossRef][Medline] [Order article via Infotrieve]
• Narita M, Shibasaki M, Mizuo K, Suzuki T (2003) Changes in G-protein activity mediated through the stimulation of dopamine and GABA(B) receptors in the mesolimbic dopaminergic system of morphine-sensitized mice . Addict Biol 8: 319-325 [Medline] [Order article via Infotrieve]
• Nishimura M, Shigi Y, Kaneto H (1990) State-dependent and/or direct memory retrieval by morphine in mice . Psychopharmacology 100: 27-30 [Medline] [Order article via Infotrieve]
• Noble F, Cox B M (1997) The role of dopaminergic systems in opioid receptor desensitization in nucleus accumbens and caudate putamen of rat after chronic morphine treatment . J Pharmacol Exp Ther 283: 557-565 [Abstract/Free Full Text]
• Powell K R, Holtzman S G (2001) Parametric evaluation of the development of sensitization to the effects of morphine on locomotor activity . Drug Alcohol Dependence 62: 83-90 [Medline] [Order article via Infotrieve]
• Power A E, Vazdarjanova A, McGaugh J L (2003) Muscarinic cholinergic influences in memory consolidation . Neurobiol Learn Mem 80: 178-193 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Ragozzino M E, Gold P E (1994) Task-dependent effects of intra-amygdala morphine injections: Attenuation by intra-amygdala glucose injections . J Neurosci 14: 7478-7485 [Abstract]
• Scheggi S, Masi F, Tagliamonte A, Gambarana C, Tolu P, De Montis M G (2000) Rats sensitized to morphine are resistant to the behavioral effects of an unavoidable stress . Brain Res 853: 290-298 [Medline] [Order article via Infotrieve]
• Serrano A, Aguilar M A, Manzanedo C, Rodriguez-Arias M, Minarro J (2002) Effects of DA D1 and D2 antagonists on the sensitization to the motor effects of morphine in mice . Progress Neuro-Psycopharmacol Biol Psychiatry 26: 1263-1271 [CrossRef]
• Stewart J, Badiani A (1993) Tolerance and sensitization to the behavioral effects of drugs . Behav Pharmacol 4: 289-312 [Web of Science][Medline] [Order article via Infotrieve]
• Tjon G H, De Vries T J, Nestby P, Wardeh G, Mulder A H, Schoffelmeer A N (1995) Intermittent and chronic morphine treatment induces long-lasting changes in delta-opioid receptor-regulated acetylcholine release in rat striatum and nucleus accumbens . Eur J Pharmacol 283: 169-176 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Ukai M, Lin H P (2002) Involvement of A1 opioid receptors and cholinergic neurotransmission in the endomorphines-induced impairment of passive avoidance learning in mice . Behav Brain Res 129: 197-201 [CrossRef][Medline] [Order article via Infotrieve]
• Vallone D, Picetti R, Borrelli E (2000) Structure and function of dopamine receptors . Neurosci Biobehav Rev 24: 125-132 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Vekovischeva O Y, Zamanillo D, Echenko O, Seppala T, Uusi-Oukari M, Honkanen A, Seeburg P H, Sprengel R, Korpi E R (2001) Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits . J Neurosci 21: 4451-4459 [Abstract/Free Full Text]
• White N M (1996) Addictive drugs as reinforcers: multiple partial actions on memory systems . Addiction 91: 921-949 [CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Zarrindast M R, Faraji N, Rostami P, Sahraei H, Ghoshouni H (2003a) Cross-tolerance between morphine- and nicotine-induced conditioned place preference in mice . Pharmacol Biochem Behav 74: 363-369 [CrossRef][Medline] [Order article via Infotrieve]
• Zarrindast M R, Gholami A, Sahraei H, Haeri-Rohani A (2003b) Role of nitric oxide in the acquisition and expression of apomorphine- or morphine-induced locomotor sensitization . Eur J Pharmacol 482: 205-213 [Medline] [Order article via Infotrieve]
• Zarrindast M R, Jafari M R, Ahmadi Sh, Djahanguiri B (2004) Influence of central administration ATP-dependent K channel on morphine state-dependent memory of passive avoidance . Eur J Pharmacol 487: 143-148 [Medline] [Order article via Infotrieve]
• Zarrindast M R, Rezayof A (2004) Morphine state-dependent learning: sensitization and interactions with dopamine receptors . Eur J Pharmacol 497: 197-204 [Medline] [Order article via Infotrieve]

This version was published on January 1, 2006

Journal of Psychopharmacology, Vol. 20, No. 1, 59-66 (2006)
DOI: 10.1177/0269881105057003


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (4) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Zarrindast, M.-R. Articles by Rezayof, A. Search for Related Content PubMed PubMed Citation Articles by Zarrindast, M.-R. Articles by Rezayof, A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB MORPHINE Social Bookmarking                         What's this?